American Journal of Immunology | |
Antitumor and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from Curcumin | Science Publications | |
Paola La Cola1  Kawkab Y. Saour1  Najim A. Al-Masoudi1  Bahjat A. Saeed1  Rita S. Elias1  | |
关键词: Dihydropyridones; curcumin; leukemia (MTT); QSAR; logP; | |
DOI : 10.3844/ajisp.2010.7.10 | |
学科分类:过敏症与临床免疫学 | |
来源: Science Publications | |
【 摘 要 】
Problem statement: Pyridones are known to have variety of biological activities like antitumor, antibacterial, antiinflamatory and antimalarial activities. This study presented antitumor evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison. Approach: The compounds evaluated for a preliminary estimation of the in vitro tumor inhibiting activity against 11 of tumor cell lines by using Microculture Tetrazolium assay (MTT) method. The method is based on the metabolic reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The cell lines of tumor subpanels were incubated within five concentrations (0.01-100
【 授权许可】
Unknown
【 预 览 】
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RO201912010159866ZK.pdf | 50KB | download |