Antitumor and Quantitative Structure Activity Relationship Study for Dihydropyridones Derived from Curcumin | Science Publications

American Journal of Immunology

Paola La Cola¹  Kawkab Y. Saour¹  Najim A. Al-Masoudi¹  Bahjat A. Saeed¹  Rita S. Elias¹ 

关键词: Dihydropyridones;    curcumin;    leukemia (MTT);    QSAR;    logP;   

DOI  :  10.3844/ajisp.2010.7.10

学科分类：过敏症与临床免疫学

来源: Science Publications

【 摘 要 】

Problem statement: Pyridones are known to have variety of biological activities like antitumor, antibacterial, antiinflamatory and antimalarial activities. This study presented antitumor evaluation of dihydropyridones derived from curcumin, as well as curcumin for comparison. Approach: The compounds evaluated for a preliminary estimation of the in vitro tumor inhibiting activity against 11 of tumor cell lines by using Microculture Tetrazolium assay (MTT) method. The method is based on the metabolic reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The cell lines of tumor subpanels were incubated within five concentrations (0.01-100

【 授权许可】

Unknown