In vitro Activation of Human and Rat Lymphocyte and Macrophage Functions by Norepinephrine | Science Publications

American Journal of Immunology

Reyes Tamez-Guerra¹  Ricardo Gomez-Flores¹  Richard J. Weber¹  Diana Caballero-Hernandez¹  Cristina Rodriguez-Padilla¹  Patricia Tamez-Guerra¹ 

关键词: Norepinephrine;    immunomodulation;    proliferation;    nitric oxide;    TNF-a;    inflammatory cytokines;    lymphocytes;    macrophages;    rat;    human;   

DOI  :  10.3844/ajisp.2005.148.153

学科分类：过敏症与临床免疫学

来源: Science Publications

【 摘 要 】

Norepinephrine (NE) has been associated not only with increasing blood pressure, atherosclerosis, heart disease, and other life threatening conditions, but also with altering immune responses by influencing leukocyte functions. In the present study, we evaluated the in vitro effects of NE on rat thymic lymphocyte and human peripheral blood mononuclear cells (HPBMC) functions. We observed that NE marginally, but significantly (P < 0.01) enhanced (1.3-fold increase) proliferation of rat thymic lymphocytes at 10-5 M, without altering HPBMC proliferation, as compared with untreated control. In addition, NE (10-5 M) significantly (P < 0.01) enhanced nitric oxide production (2.9

【 授权许可】

Unknown