Evaluation of Antimicrobial Activity of Cuminum Cyminum Essential Oil and Extract against Bacterial Strains Isolated from Patients with Symptomatic Urinary Tract Infection

Novelty in Biomedicine

Hossein Goudarzi¹  Fatemeh Fallah¹  Masoud Dadashi¹  Soudabeh Taheri¹  Yasaman Saee²  Gita Eslami¹ 

[1] Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Microbiology,Islamic Azad University , Pharmaceutical Sciences Branch,Tehran,Iran

关键词: Antimicrobial activity;    Cuminum cyminum L.;    essential oil;    extract;   

DOI  :  

学科分类：生物科学（综合）

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Background: Many efforts have been done to find effective agents against resistant pathogens. Cuminum cyminum L. (Cumin) is an aromatic plant within the Apiaceae family. It has a variety of purposes and demonstrates antimicrobial and antioxidant properties. This study evaluated the activity of C. cyminum extract and essential oil against bacterial isolates which cause urinary tract infection, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus agalactiae, group A streptococci, Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus and Staphylococcus saprophyticus isolated from patients with urinary tract infection. Materials and Methods:Extract was prepared by maceration and essential oil was prepared by hydrodistillation fromC. cyminumseeds. The study population was 95 patients with urinary tract infection without malignant diseases, diabetes and immunosupression. After identification of organism, susceptibility testing was carried out by disc diffusion method and MIC values by broth microdilution testing. Results: C. cyminumessential oil can have a better effect on the gram-negative bacteria causing urinary tract infection than gram-positive bacteria. In addition,C. cyminumextract have good activity against both gram- positive and gram-negative bacteria. Our findings also showed that essential oil and extract ofC. cyminumhas better antibacterial activity on uropathogen isolates than amoxicillin and the difference was significant ( P value<0.05 ) but the activity is not superior to other antibiotics. Conclusion:These results suggest that the essential oil and extract ofC. cyminumseeds might be considered as interesting sources of antibacterial components against uropathogenic bacteria.

【 授权许可】

Unknown