Probiotics: an update on mechanisms of action and clinical applications

Novelty in Biomedicine

Hossein Goudarzi¹  Mehdi Goudarzi¹  Marjan Rashidan¹ 

[1] Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences

关键词: Probiotics;    Lactobacillus;    Bifidobacterium;    UTI;   

DOI  :  

学科分类：生物科学（综合）

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Probiotics are live microbial feed supplement and can provide health benefit to the host if administered in sufficient amounts. The most predominant species that have been used as probiotic includeLactobacilliandbifidobacteria.Proper administration of probiotics could be efficient in the treatment of various disorders. However; their mechanism of action is poorly understood. The effects of probiotics may be classified in following modes: reinforcement of the intestinal mucosal barrier against pathogens, competition with pathogens for adherence to the mucosa and epithelium, competitive exclusion of pathogenic microorganisms, production of antimicrobial substances, modulation of the immune system and interference with quorum sensing signaling. Exploration of the clinical features of probiotic strains, their modes of action and investigation based on probiotic therapy may be beneficial in treatment of various diseases.

【 授权许可】

Unknown