Use of tranexamic acid as a therapeutic variant in patients having high digestive blooding not from varix

Revista Cubana de Cirugía

Hospital Universitario General Calixto García, La Habana, Cuba¹  Milián Valdés, Davel¹  Pulido Barrientos, Osniel¹  Pérez Chávez, Pedro Julio¹  Larrea Fabra, Martha E¹  Falcón Córdova, Katty¹  González Sosa, Gabriel¹ 

关键词: non-variceal upper gastrointestinal bleeding;    tranexamic acid.;   

DOI  :  

学科分类：外科医学

来源: SciELO

【 摘 要 】

Introduction: Non-variceal upper gastrointestinal bleeding is one of the first causes of hospitalization in our country and it has become a serious and sensitive health problem in the last few years.Objective: To characterize the behaviour of the demographic, clinical and therapeutic variables found in patients admitted to the emergency general surgery service of ¨General Calixto Garcia¨ university hospital due to this disease from June 2012 to December 2013.Methods: Observational, analytical, prospective and postmarket surveillance study to prove the effectiveness of the tranexamic acid as an early therapeutic variant to stop bleeding and avoid re-bleeding in those patients with non-variceal upper gastrointestinal bleeding.Results: In the study group of 104 patients, males and over 70 years-old people predominated for 61.5% and 37.5%, respectively. The coffee overconsumption was seen in 94%, more than 50% took alcohol and 37% had non-steroidal antinflammatory drugs treatment. Of the total number of patients, 61.5% and 55.8% suffered blood hypertension and chronic gastritis, respectively. Melena was the most frequent presentation of this disease; urgent endoscopoy was performed in just 25% of casos and the predominant diagnosis was erythematous pangastritis in 51.1% of patients. The surgical treatment was used in just 2.5% of the study patients, the lenght of stay at hospital was less than 3 days in 84% and very low overall mortality rate of 1.9%.Conclusions: The effects of the tranexamic acido n patients with non-variceal upper gastrointestinal bleeding were benefitial for treating the disease; evidence of active bleeding after the use of drug significantly decrease, surgical treatment was an exception and mortality rate was very low. 

【 授权许可】

Unknown