Study Of Prevention Of Post-Partum Haemorrhage After Caesarean Section With Use Of Tranexamic Acid.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Suhas Shinde¹  Prashant Padmakar Zende¹  Sai Waikar.¹ 

[1] Department of Obstetrics and Gynaecology, DVVPF'S Medical College and Hospital

关键词: Postpartum haemorrhage;    caesarean section;    tranexamic acid.;   

DOI  :  10.33887/rjpbcs/2022.13.5.25

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Postpartum haemorrhage (PPH) is one of the leading cause of maternal mortality and morbidity.Haemostatic imbalance due to tissue plasminogen activator (tPA) release, subsequently leading tohyperfibrinolysis is said to have an important role in the pathogenesis of PPH. Antifibrinolytics such astranexamic acid (TXA) is commonly used in haemorrhagic disorders with the above pathogenesis. ThusTXA use is a part of PPH treatment recommended, and recently, studies have assessed the effectiveness ofprophylactic use of TXA in reducing the incidence and severity of PPH. This prospective comparativestudy was conducted in Dr. Vitthalrao Vikhe Patil Foundation’s Medical College and Memorial Hospital,Ahmednagar, after permission from ethical committee, in the period from January 2021 to January 2022and included a total of 200 pregnant women with a previous caesarean section (para1-CS), who wererandomized into two groups of 100 pregnant women each and who underwent elective caesarean sectionunder spinal anaesthesia. The amount of blood loss was significantly lower in the study group than in thecontrol group (416.1289.95 and 688.68134.77, respectively). Also, the 24-h postoperative haemoglobinwas significantly higher in the study group (11,660.79 mg/dl) compared to the control group (10,531.07mg/dl), and the 24-h postoperative hematocrit was significantly higher in the study group ( 34.992.40)compared to the control (31.623.22). Prophylactic administration of tranexamic acid reducesintraoperative and postoperative bleeding from cesarean sections and the incidence of postpartumhaemorrhage.

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