Hypolipidemic and antiatherogenic effects of Cynara scolymus in cholesterol-fed rats

Revista Brasileira de Farmacognosia

Duarte, Marta M.M.F.¹  Mocelin, Ricieri¹  Sachett, Adrieli¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil¹  Universidade Luterana do Brasil, Canoas, Brazil¹  Zanatta, Leila¹  Conterato, Greicy M.M.¹  Universidade Federal de Santa Catarina, Florianópolis, Brazil¹  Marcon, Matheus¹  Schönell, Amanda P.¹  Santo, Glaucia D.¹  Universidade Comunitária da Região de Chapecó, Chapecó, Brazil¹  Wildner, Silvana M.¹  Gomes, Denise B.¹  Roman Junior, Walter A.¹  Bevilaqua, Fernanda¹  Giachini, Marta¹  Chitolina, Rafael¹  Piato, Angelo L.¹ 

关键词:  Antihyperlipidemic;    Antiatherogenic;    Artichoke;    Asteraceae;    Cholesterol;   

DOI  :  10.1016/j.bjp.2015.11.004

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Cynara scolymus L., Asteraceae, are traditionally used to treat dyspepsia. This study evaluated the hypolipidemic and antiatherogenic effects of an aqueous extract prepared from the leaves of C. scolymus in rat's model. Hypercholesterolemic rats (1% cholesterol and 0.5% cholic acid for 15 days) were treated (0.5 ml/200 g) with extract of C. scolymus (150, 300, or 600 mg/kg p.o.; n = 6) or simvastatin (4 mg/kg p.o.; n = 6) once per day for 30 days along with hypercaloric diet. A control group (C) was given water (0.5 ml/200 g; n = 6). A high-cholesterol diet was maintained throughout the treatment period. Rats treated with extract of C. scolymus (150, 300, or 600 mg/kg) and simvastatin showed significant decreases in serum levels of total cholesterol (−46.9%, −51.9%, −44%, and −41.9%, respectively) and low-density lipoprotein-cholesterol (LDL-C; −52.1%, −54.8%, −51.9%, and −46.7%, respectively), compared with group C (p < 0.005). Biochemical analyses revealed significant decrease in the concentration of IL-1, IL-6, TNF-α, IFN-γ, C-reactive protein, oxidized-LDL, and antioxidized-LDL in rats treated with extract of C. scolymus (150, 300, or 600 mg/kg). There were no differences in serum ALT enzyme activity between the groups. Our results suggest that hypolipidemic and antiatherogenic effects could be related with the presence of polar substances present in aqueous extract of C. scolymus.

【 授权许可】

Unknown