Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats

Revista Brasileira de Farmacognosia

University of KwaZulu-Natal, Pietermaritzburg, South Africa¹  Duraipandiyan, Veeramuthu¹  King Saud University, Riyadh, Saudi Arabia¹  Sunil, Christudas¹  St Joseph College of Pharmaceutical Sciences, Cherthala, India¹  Irudayaraj, Santiagu Stephen¹  Loyola College, Chennai, India¹  Al-Dhabi, Naif Abdullah¹ 

关键词:  Friedelin;    High-fat diet model;    Triton WR-1339;    Hyperlipidemia;    Fenofibrate;   

DOI  :  10.1016/j.bjp.2015.07.025

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The hypolipidemic activity of friedelin isolated from Azima tetracantha Lam., Salvadoraceae, was studied in Triton WR-1339 and high-fat diet-induced hyperlipidemic rats. In Triton WR-1339 induced hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) showed a significant (p < 0.01) lipid-lowering effect as assessed by reversal of plasma levels of total cholesterol (TC), triacylglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). In high-fat diet fed hyperlipidemic rats, treatment with friedelin (50 and 70 mg/kg) caused lowering of lipid levels in plasma and liver. The hypolipidemic activity of friedelin was compared with fenofibrate, a known lipid-lowering drug, in both models.

【 授权许可】

Unknown