Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria

Lipids in Health and Disease

Min Zhang¹  Yan Wang¹  Qiu Bing²  Qingju Liu²  Xin Gao³  Xia Gao⁴  Yanhong Suo⁴ 

[1]0000 0004 1761 9803, grid.412194.b, Ningxia Medical University, 750000, Yinchuan City, China

[2]0000 0004 1797 6990, grid.418117.a, Gansu University of Chinese Medicine, 730000, Lanzhou City, China

[3]grid.417234.7, Intensive Care Unit, Gansu Provincial Hospital, 730000, Lanzhou City, China

[4]grid.417234.7, Pediatric Department, Gansu Provincial Hospital, No. 204 Donggang West road, 730000, Lanzhou City, China

关键词: Hyperlipidemia;    Angiopoietin-like protein 3;    24 h urine protein;   

DOI  :  10.1186/s12944-019-1052-1

来源: publisher

【 摘 要 】

BackgroundAngiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been enough data to explain the mechanism of hyperlipidemia related proteinuria. In this study, we hoped to investigate the changes of Angiopoietin-like protein 3(ANGPTL3) levels in hyperlipidemia patients with different proteinuria levels.MethodsSeventy-one patients with hyperlipidemia were selected, who were hospitalized in Gansu Provincial People’s Hospital from September 2016 to September 2017, and 20 healthy people in the physical examination center were selected. We combed through medical history and conducted clinical biochemical indicators of blood urea nitrogen (BUN), serum creatinine (SCr), 24 h urine protein quantitation (24hUPro), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low detection of density lipoproteins (LDL-C). The concentration of serum ANGPTL3 was measured by ELISA.Results1. Serum ANGPTL3 in patients with hyperlipidemia related proteinuria was higher than that in the control group, and the difference was statistically significant (p < 0.05); 2. 24hUPro and BMI (r = 0.321, P = 0.002), TC (r = 0.465, P = 0.000), TG (r = 0.281, P = 0.007), LDL (r = 0.478, P = 0.000) in patients with hyperlipidemia related proteinuria are positively correlated, suggesting that dyslipidemia is related to the occurrence of proteinuria; 3. BMI, TC, TG and LDL in patients with hyperlipidemia related proteinuria were positively correlated with serum ANGPTL3. 4. The 24hUPro of patients with hyperlipidemia related proteinuria was positively correlated with serum ANGPTL3 levels, and BUN and SCr were not associated with serum ANGPTL3 level. 5. There was no significant difference in TC, TG, BMI, 24hUPro and serum ANGPTL3 between the statin-treated and the untreated groups in patients with hyperlipidemia related proteinuria.ConclusionsAngiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria.

【 授权许可】

CC BY