Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats

Revista Brasileira de Farmacognosia

Afyon Kocatepe University, Afyonkarahisar, Turkey¹  Demirel, Murside Ayse¹  Akkol, Esra Kupeli¹  Keles, Hikmet¹  Suntar, Ipek¹  Ilhan, Mert¹  Gazi University, Ankara, Turkey¹ 

关键词:  Betulaceae;    Corylus avellana;    Phytosterol;    Letrozole;    Polycystic ovary syndrome;    Antioxidant;   

DOI  :  10.1016/j.bjp.2015.09.009

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxide dismutase, malondialdehyde, catalase, glutathione peroxidase levels. The phytosterol content of the oil was determined by HPLC. The plasma high density lipoprotein-cholesterol level was found to be significantly high and leptin and glucose concentrations were found to be significantly low in the treatment group. According to the phytochemical analysis, the main components of the oil were detected as α-tocopherol, γ-tocopherol, squalene, β-sitosterol, campesterol and stigmasterol. Corylus avellana oil was found to be effective in the treatment of polycystic ovary syndrome via regulating gonadotropins, steroids and serum lipid parameters and possesses antioxidant activity.

【 授权许可】

Unknown