Revista Brasileira de Farmacognosia | |
Antinociceptive activity of Sargassum polyceratium and the isolation of its chemical components | |
Santos, Aline Kely Felício de Sousa1  Fonseca, Diogo Vilar da1  Pordeus, Liana Clébia de Morais1  Dias, Celidarque da Silva1  Torres, Paula de Arruda1  Barbosa-Filho, José Maria1  Almeida, Reinaldo Nobrega de1  Muniz, Vanessa Morais1  Lira, Narlize Silva1  Salgado, Paula Regina Rodrigues1  Universidade Federal da Paraíba, João Pessoa, Brazil1  | |
关键词: Â Antinociceptive; Sargassum polyceratium; Marine algae; Pain; Porphyrin compounds; | |
DOI : 10.1016/j.bjp.2015.07.017 | |
来源: Sociedade Brasileira de Farmacognosia | |
【 摘 要 】
Marine algae have been the focus of important studies over the past fifty years, with a considerable number of components important to chemists and taxonomists having been isolated and characterized. The scientific data available on Sargassum polyceratium are extremely limited. The objective of the present study was to evaluate the antinociceptive activity of an ethanol extract of S. polyceratium and to isolate its components. Intraperitoneal treatment with ethanol extract of S. polyceratium reduced the number of acetic acid-induced writhes and the amount of time spent in paw-licking in the second phase of the formalin test. Ethanol extract of S. polyceratium also reduced the amount of time spent in paw-licking in the glutamate test; however, there was no difference in the reaction time in the hot plate test at any of the doses tested. The chemical components isolated from ethanol extract of S. polyceratium were identified using one- and two-dimensional spectroscopic methods such as infrared spectroscopy, mass spectrometry and 1H and 13C nuclear magnetic resonance spectroscopy. The analytical results were also compared with data obtained in the literature. The following porphyrin derivatives were isolated from S. polyceratium: 132-hydroxy-(132-R)-pheophytin-a, 132-hydroxy-(132-S)-pheophytin-a, pheophytin-a, and the steroid fucosterol. The present results indicate that the ethanol extract of S. polyceratium has antinociceptive activity. In addition, four new substances were isolated from the species evaluated.
【 授权许可】
Unknown
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