In vitro photoprotective effects of Marcetia taxifolia ethanolic extract and its potential for sunscreen formulations

Revista Brasileira de Farmacognosia

Costa, Sônia C.C.¹  Botura, Mariana B.¹  Branco, Carla R.C.¹  Universidade Estadual de Feira de Santana, Feira de Santana, Brazil¹  Detoni, Cassia B.¹  Branco, Alexsandro¹ 

关键词:  Marcetia taxifolia;    Flavonoid;    Photoprotective;    Sunscreen formulation;   

DOI  :  10.1016/j.bjp.2015.07.013

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The species Marcetia taxifolia (A. St.-Hil.) DC., Melastomataceae, which is endemic of the rupestrian fields of northeastern Brazil, contains a significant amount of flavonoids. In this work, the potential of the ethanolic extract of M. taxifolia as the active principle in a sunscreen photoprotection (UV-A and UV-B) formulation was investigated. The Liquid Chromatography High Performance-Diode Array Detector quantification (quercetin), total flavonoid content, antioxidant activity through 2.2-diphenyl-1- picrylhydrazil method, photoprotective activity against UV-B and UV-A radiation in vitro (spectrophotometric method) and potential for eye irritation using the methodology of the hen egg test-chorioallantoic membrane were performed in the extract. After that, the formulations were prepared using different concentrations of active ethanolic extract (5, 10, 20 and 30%) and the evaluation of the sun protection factor was carried out using the same methodology used for the crude extract. The crude extract showed UV-A photoprotection and low eye irritation in the hen egg test-chorioallantoic membrane test. All formulations containing M. taxifolia extract had ≥ 6 sun protection factor. Its shows the possibility to use this extracts as a sunscreen in pharmaceutical preparations.

【 授权许可】

Unknown