Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda

Revista Brasileira de Farmacognosia

Universidade Estadual Paulista, Araraquara, BR¹  Sociedade Brasileira de Fisiologia, São Paulo, BR¹  Universidade Federal de Viçosa, Viçosa, BR¹  Rocha, Cláudia Q. da¹  Santa-Cecília, Flávia V.¹  Vilegas, Wagner¹  Cavalcante, Gustavo P.¹  Universidade Federal de Alfenas, Alfenas, BR¹  Santos, Marcelo H. dos¹  Vilela, Fabiana C.¹  Giusti-Paiva, Alexandre¹ 

关键词:   Arrabidaea brachypoda;    Inflammation;    Natural product;    Pain;    Triterpene;   

DOI  :  10.1016/j.bjp.2015.03.005

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Arrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use.

【 授权许可】

Unknown