Revista Brasileira de Farmacognosia | |
Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda | |
Universidade Estadual Paulista, Araraquara, BR1  Sociedade Brasileira de Fisiologia, São Paulo, BR1  Universidade Federal de Viçosa, Viçosa, BR1  Rocha, Cláudia Q. da1  Santa-Cecília, Flávia V.1  Vilegas, Wagner1  Cavalcante, Gustavo P.1  Universidade Federal de Alfenas, Alfenas, BR1  Santos, Marcelo H. dos1  Vilela, Fabiana C.1  Giusti-Paiva, Alexandre1  | |
关键词: Â Arrabidaea brachypoda; Inflammation; Natural product; Pain; Triterpene; | |
DOI : 10.1016/j.bjp.2015.03.005 | |
来源: Sociedade Brasileira de Farmacognosia | |
【 摘 要 】
Arrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use.
【 授权许可】
Unknown
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