Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents

BMC Complementary and Alternative Medicine

Jackson Roberto G da S Almeida²  Lucindo J Quintans-Júnior¹  Adriana G Guimarães¹  Rosemairy L Mendes²  Raimundo C Palheta-Júnior²  Carlos Wagner de S Wanderley²  Tâmara C Diniz²  Raimundo G de Oliveira-Junior²  Sarah Raquel G de Lima-Saraiva²  Camila de S Araújo²  Juliane C Silva² 

[1] Department of Physiology, Federal University of Sergipe (DFS/UFS), São Cristóvão, 49.100-000, Sergipe, Brazil;Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, 56.304-205, Pernambuco, Brazil

关键词: Annona vepretorum;    Inflammation;    Pain;   

Others  :  1217042
DOI  :  10.1186/s12906-015-0716-2

 received in 2014-09-01, accepted in 2015-06-09,  发布年份 2015

【 摘 要 】

Background

Annona vepretorum Mart. (Annonaceae) is a native tree from Caatinga (Brazilian Northeastern savanna biome), popularly known as “araticum” and “pinha da Caatinga”. In this study, we investigated the effects of the crude ethanolic extract (Av-EtOH) in models of pain and inflammation in rodents.

Methods

The evaluation of antinociceptive activity was carried out by the acetic acid-induced writhing, formalin, hot plate and tail flick tests, while paw edema induced by carrageenan or histamine, and leukocyte migration to the peritoneal cavity were used for anti-inflammatory profile. Histological analyses also were carried out.

Results

Av-EtOH (25, 50 and 100 mg/kg, p.o) significantly reduced the number of writhing (P < 0.01) and decreased (P < 0.01) the paw licking time in both phases of the formalin test. In the hot plate and tail flick tests, this extract increased the reaction time, consequently reduced painful behavior. The effects in the formalin and hot plate tests were antagonized by naloxone. Av-EtOH inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan and histamine. In the peritonitis test, acute pre-treatment with Av-EtOH inhibited leukocyte migration. Histological analysis showed less inflammation in the groups treated with the extract when the inflammation was induced by carrageenan or histamine.

Conclusion

Thus, Av-EtOH has significant antinociceptive and anti-inflammatory properties, which are related probably with the activation of opioid receptors and inhibition of release of mediators of the inflammatory process. This specie is a potential target for drug discovery.

【 授权许可】

   
2015 Silva et al.

【 图 表 】

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