Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity

Revista Brasileira de Farmacognosia

Biavatti, Maique W.¹  Barison, Andersson¹  Santos, Alan Diego C.¹  Lima, Tamires C.¹  Souza, Rafaela J.¹  Steindel, Mário¹  Universidade Federal do Paraná, Curitiba, BR¹  Universidade Federal de Santa Catarina, Florianópolis, BR¹  Costa, Danielle T.M.¹ 

关键词: Asteraceae;    Calea pinnatifida;    Chromenes;    Leishmanicidal activity;   

DOI  :  10.1016/j.bjp.2015.01.004

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Calea pinnatifida (R. Br.) Less., Asteraceae, is popularly known as “quebra-tudo”, “cipó-cruz” or “aruca”. This species is used in the folk medicine for the treatment of stomach pain, giardiasis and amoebiasis. The aim of this study was to isolate and identify chromenes from leaves of C. pinnatifida and evaluate their leishmanicidal activity. A fraction from leaves of C. pinnatifida was analyzed for their chemical constituents, resulting in the isolation and characterization of four known chromenes: 6-acetyl-7-hydroxy-2,2-dimethylchromene (1), 6-acetyl-7-methoxy-2,2-dimethylchromene (2), 6-(1-hydroxyethyl)-7-methoxy-2,2-dimethylchromene (3) and 6-(1-ethoxyethyl)-7-methoxy-2,2-dimethylchromene (4). Structure identification of isolated compounds involved analysis of spectral data of 1D and 2D-NMR. The isolated compounds are here reported for the first time in C. pinnatifida, and the chromenes 1 and 3 show a moderate leishmanicidal activity.

【 授权许可】

Unknown