Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus

Revista Brasileira de Farmacognosia

Universidade Federal de Sergipe, Brazil¹  Oliveira, Hiagno A.¹  Oliveira, Claudenice S.¹  Santos, Getisêmani K. M.¹  Trindade, Rita de C.¹  Oliveira, Roseli F.¹  Ribeiro, Paulo R.¹  Universidade Católica do Salvador, Brazil¹  Silva, Pompilio R. C.¹  Universidade Federal da Bahia, Brazil¹  Fernandez, Luzimar G.¹ 

关键词: Abarema cochliacarpos;    barbatimão;    hepatic congestion;    medical plants;    steatosis;   

DOI  :  

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Abarema cochliacarpos (Gomes) Barneby & J.W. Grimes, Fabaceae, is a native species of Brazil popularly known as "barbatimão", frequently found along the north coast of the state of Bahia. Local communities make an infusion from its stem bark, which is used to treat several diseases. This study aimed to evaluate the hepatotoxicity of A. cochliacarpos extracts in mice Mus musculus. The bark infusion and hydroalcoholic extract were administered nasogastrically into two groups of eight animals (four male and four female each). After 45 days all mice were killed and the livers were collected for further histological analysis. Hepatic steatosis, congestion of the hepatic vessels and medicinal plantspresence of macrophages and lymphocytes infiltrates in the liver, were observed in both steatosis group of animals, additionally animals that received the stem bark infusion presented an accumulation of pigments. None of the animals belonging to the negative control group showed any of the symptoms described above. In conclusion, the hydroalcoholic extract and infusion of A. cochliacarpos stem bark were proven to cause intoxication in mice. The hepatotoxicity of the infusion was more aggressive in females. Further studies are necessary to isolate compounds responsible for the toxic characteristics of A. cochliacarpos.

【 授权许可】

Unknown