期刊论文详细信息
Revista Brasileira de Farmacognosia
Evaluation of antinociceptive and anti-inflammatory activities of extract and fractions of Eugenia jambolana root bark and isolation of phytoconstituents
Jadavpur University, India1  Nitte University, India1  Mandal, Shubhash C.1  Saha, Santanu1  Kodangala, Chandrashekar1  Shastry, Shashidhara C.1  Manipal University, India1  Subrahmanyam, E. V. S1  Srinivas College of Pharmacy, Vallachil, India1 
关键词: adjuvant induced arthritis;    anti-inflammatory;    antinociceptive;    formalin induced nociception;    Eugenia jambolana;    Myrtaceae;   
DOI  :  
来源: Sociedade Brasileira de Farmacognosia
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【 摘 要 】

Eugenia jambolana Lam., Myrtaceae, is a widely distributed and traditionally well known plant in India. The root bark of the plant was extracted with ethanol and then successively fractionated into petroleum ether fraction, chloroform fraction, n-butanol fraction and methanol fraction. The extract and fractions of the plant material were evaluated for the antinociceptive activity by acetic acid-induced writhing test and formalin-induced nociception test, and anti-inflammatory activity was screened by carrageenan-induced rat paw edema, cotton pellet induced granuloma formation and adjuvant induced arthritis in rat models. The test materials showed the antinociceptive and anti-inflammatory effect in dose dependent manner and the petroleum ether fraction was found to be most potent among the test materials. At 400 mg/kg b.w., p.o. dose petroleum ether fraction significantly inhibited 54.28% writhing response and 73.77% formalin induced nociception in mice. The fraction with same dose showed significant 79.31% inhibition of carrageenan-induced rat paw edema, 57.78% anti-proliferative effect and 77.93% inhibition of adjuvant induced arthritis. The bioactive petroleum ether fraction was then subjected to column chromatography which led to isolate three compounds, namely, β-sitosterol, stigmasterol and lupeol. These compounds were characterized and identified by IR, 1H NMR, 13C NMR and mass spectroscopy.

【 授权许可】

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