Evaluation of anticonvulsant activity of ethanolic leaves extract of Desmodium triflorum in mice

Revista Brasileira de Farmacognosia

Einstein, John Wilking¹  Mathai K, Benson¹  St. John’s Pharmacy College, Bangalore, India¹  Gowda, Girish¹  Das, Kuntal¹  Bhosle, Vaibhav¹ 

关键词: anticonvulsant activity;    Desmodium triflorum;    isoniazid;    maximal electroshock;    pentylenetetrazole.;   

DOI  :  10.1590/S0102-695X2012005000019

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The present investigation was aimed to study an anticonvulsant activity of ethanolic extract of Desmodium triflorum (L.) DC., Fabaceae, in mice. Animal models of epilepsy namely the pentylenetetrazole (PTZ), isoniazid or isonicotinic hydrazide (INH) and maximal electroshock induced convulsion (MES) were used to evaluate the anticonvulsant effects of the extracts. The biochemical estimation was done by measuring the lipid peroxidation and reduced glutathione (GSH). In the PTZ induced convulsion, ethanolic extract of D. triflorum (EEDT) 400 mg/kg significant delayed the onset of convulsion, reduced the duration of convulsion and reduced mortality. Similarly a dose of 800 mg/kg of EDDT significantly delayed the onset of convulsion, reduced the duration of convulsion and showed 33.33% protection in mice against INH induced convulsion. Further no mortality was found. Both the doses reduced hind limb tonic extension (HLTE) phase of MES induced convulsion in mice. The pretreated EEDT showed significant inhibition of lipid peroxidation and increases the reduced glutathione level in mice brain tissue. The results revealed that D. triflorum possesses a significant dose dependent anticonvulsant activity.

【 授权许可】

Unknown