Antiulcer effect of epoxy-carvone

Revista Brasileira de Farmacognosia

Universidade Federal de Sergipe, Brazil¹  Batista, Josemar S.¹  Silva, Jaciara P.¹  Siqueira, Bruna P. J.¹  Sousa, Damião P. de¹  Menezes, Crislaine T.¹ 

关键词: epoxy-carvone;    essential oil;    ethanol-induced gastric ulcer;    gastroprotective activity;    indomethacin-induced gastric ulcer;    monoterpene;   

DOI  :  10.1590/S0102-695X2011005000172

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Epoxy-carvone is a monoterpene present in essential oils of various plants. It is a derivative of carvone, which has an epoxy group instead of the α- and β-unsaturated ketone group present in carvone. As recent studies have shown that several alcohol terpenes and compounds containing α, β-unsaturated ketone groups present antiulcer effect, the main of the present study was to evaluate the antiulcer effect of epoxy-carvone. The models of ulcers induced by ethanol and indomethacin were used in this study. Epoxy-carvone at the dose of 1 mg/kg did not present antiulcer effect against ulcer induced by ethanol, but at the doses of 10, 30 and 50 mg/kg it presented gastroprotective effect in both ulcer models. Epoxy-carvone also did not affect the gastric secretion in the pylorus ligation test. Moreover, pretreatment with indomethacin or L-nitroarginine methyl ester did not reverse the gastroprotection produced by this monoterpene. This study showed that epoxy-carvone presents antiulcer effect and suggests that this effect does not involve either antisecretory activity or increase of the nitric oxide and prostaglandin synthesis.

【 授权许可】

Unknown