Chemical composition and antiproliferative activity of essential oil from aerial parts of a medicinal herb Artemisia herba-alba

Revista Brasileira de Farmacognosia

Chait, Abderrahman¹  Jaafari, Abdeslam¹  Mouse, Hassan Ait¹  Aboufatima, Rachida¹  Sultan Moulay Slimane University, Morocco¹  Tilaoui, Mounir¹  Zyad, Abdelmajid¹  Cadi Ayyad University, Morocco¹ 

关键词: aerial parts;    anticancer activity;    Artemisia herba-alba;    composition;    essential oil;   

DOI  :  10.1590/S0102-695X2011005000114

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Artemisia herba-alba Asso., Asteraceae, is widely used in Morrocan folk medicine for the treatment of different health disorders. However, no scientific or medical studies were carried out to assess the cytotoxicity of A. herba-alba essential oil against cancer cell lines. In this study, eighteen volatile compounds were identified by GC-MS analysis of the essential oil obtained from the plant's aerial parts. The main volatile constituent in A. herba-alba was found to be a monoterpene, Verbenol, contributing to about 22% of the total volatile components. The essential oil showed significant antiproliferative activity against the acute lymphoblastic leukaemia (CEM) cell line, with 3 µg/mL as IC50 value. The anticancer bioactivity of Moroccan A. herba-alba essential oil is described here for the first time.

【 授权许可】

Unknown