Cytotoxic, antitumor and leukocyte migration activities of resveratrol and sitosterol present in the hidroalcoholic extract of Cissus sicyoides L., Vitaceae, leaves

Revista Brasileira de Farmacognosia

Souza, Valdênia M. O.¹  Federal University of Pernambuco, Recife, Brazil¹  Almeida, Edvaldo R.¹  Silva, Teresinha G.¹  Aguiar, Jaciana S.¹  Nascimento, Silene C.¹  University of Pernambuco, Recife, Brazil¹  Lucena, Flávia R. S.¹ 

关键词: Cissus sicyoides;    antitumor activity;    leukocyte migration;    activation of lymphoid lineage.;   

DOI  :  10.1590/S0102-695X2010005000002

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Cissus sicyoides L. pertains to the Vitaceae family. It is popularly known as "insulina, cipo-pucá, bejuco caro, puci, anil trepador". A vasoconstrictor effect and an antibacterial activity have also been allocated to it. In Brazil, C. sicyoides was evaluated for its anticonvulsant and anti-diabetc properties. Phytochemistry studies identified and isolated sitosterol and resveratrol compounds from its aerial parts which are pointed out as having antitumor activities. The goal of this study was to investigate the cytotoxic and antitumor activities of Cissus sicyoides hydroalcoholic extract as well as its ability to repair leukocytes cells to injured tissue. Cissus sicyoides did not demonstrate cytotoxic activity but showed an inhibition of tumor growth in face of the tumors tested. The extract had a strong chemotactic effect on the twenty four hours period after treatment. The hidroalchoolic extract of Cissus sicyoides presented antitumor activity which was prompted by T lymphocytes recruitment to the local lesion and suggests a new pathway to antitumor activity by activation of lymphoid lineage.

【 授权许可】

Unknown