期刊论文详细信息
Brazilian Archives of Biology and Technology
Evaluation of the Antidiabetic and Antibacterial Activity of Cissus sicyoides
Flavio Luis Beltrame2  Greisiele Lorena Pessini2  Dani Luce Doro2  Benedito Prado Dias Filho1  Roberto Barbosa Bazotte2  Diógenes Aparício Garcia Cortez2 
[1] ,Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia
关键词: Cissus sicyoides;    Vitaceae;    experimental diabetes mellitus;    antibiosis;    steroids;   
DOI  :  10.1590/S1516-89132002000100004
来源: SciELO
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【 摘 要 】

In this work we investigated the antidiabetic and antibacterial effect of Cissus sicyoides (CS) from Brazil. Diabetic rats that received water (A group) or extracts from the aerial parts of the plant (Cs group) during four weeks were employed. After this period, serum levels of glucose, cholesterol and triglycerides were measured. Glycemia was not affected by treatment with CS. However, there was an increased cholesterol and triglyceride level in Cs group. In addition, bioassay-guided fractionation of methanolic extract from aerial parts of CS was performed for isolation of antibacterial compounds.beta-Sitosterol and sitosterol-beta-D-glucopyranoside isolated showed antibacterial activity against Bacillus subtilis with minimal inhibitory concentrations (MICs) of 50 mug/ml and 100 mug/ml, respectively. In spite of popular belief, CS did not show antidiabetic activity. However, two compounds isolated from aerial parts of the plant (beta-sitosterol and sitosterol-beta-D-glucopyranoside) showed antibacterial activity.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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