Evaluation hematological and biochemical parameters of rats in the second thirds of the gestation submitted to the action of the extract methanol of Cereus jamacaru DC., Cactaceae

Revista Brasileira de Farmacognosia

Bastos, Isla V. G. A.¹  Messias, Júlio B.¹  Souza, Ivone A.¹  Faculdade Maurício de Nassau, Recife, Brasil¹  Guerra, Martha de O.¹  Caraciolo, Mércia C. M.¹  Montarroyos, Ulisses R.¹  Universidade Federal de Pernambuco, Vitória de Santo Antão, Brasil¹  Oliveira, Inalda M. de¹  Universidade Federal de Pernambuco, Recife, Brasil¹  Fiocruz, Recife, Brasil¹  Universidade de Pernambuco, Recife, Brasil¹  Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil¹ 

关键词: Cereus jamacaru;    mandacaru;    pregnancy;    hematology;    biochemistry.;   

DOI  :  10.1590/S0102-695X2010000400003

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The effects of oral administration of methanol extract (ME) prepared from stems of Cereus jamacaru DC., Cactaceae were investigated on the biochemical and hematological parameters in pregnant adult Wistar rats. Twenty rats (n = 5 per group) have been treated orally for four consecutive days with ME in doses of 100, 250 and 500 mg/kg weight, and then, it was determined the biochemical and hematological profiles. The results showed that during the period of treatment there was no signs of toxicity or death. The hematological and biochemical parameters were not modified by oral administration of ME, except for a significant increase of 45.7% and 41.9% for alanine transaminase (ALT) in doses of 250 and 500 mg/kg in addition to the significant increase, of to 48.2%, 39.8% and 41.8% for aspartate transaminase (AST). In hematology, it was registered a fluctuation within the reference values of hemoglobin in the differential count of neutrophil and lymphocyte. In this way the administration of methanol extract of C. jamacaru does not produce toxic effects or alters the majority of biochemical and hematological studies in pregnant adult Wistar rats. However, the increase of serum ALT and AST in high doses suggests a liver overload, which must be investigated in more detail.

【 授权许可】

Unknown