Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models

Revista Brasileira de Farmacognosia

Tavares, Adriano¹  Paula, José Realino de¹  Costa, Elson Alves¹  Guimarães, Heloisa Alves¹  Galdino, Pablinny Moreira¹  Federal University of Goiás, Goiânia, Brazil¹  Nascimento, Marcus Vinícius M.¹ 

关键词: Pain;    inflammation;    leaf extract;    Lafoensia pacari;    Lythraceae.;   

DOI  :  10.1590/S0102-695X2010000300007

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Lafoensia pacari A. St.-Hil., Lythraceae, popularly known as pacari, is a Cerrado's native specimen; the stem bark extract is used in folk for pain and inflammation, also showing sedating activity. This study aimed to evaluate the analgesic and anti inflammatory activities of ethanol extract from pacari leaves (EEPL). These activities were verified in mice. The previous treatment with EEPL 1.0 g/kg showed antinociceptive activity both in the acetic acid-induced writing test and in the formalin-induced model of pain, and in neurogenic and inflammatory phases as well. In the croton oil-induced ear edema, the pre-treatments with EEPL reduced the edema in a dose-dependent manner. Also in the carrageenan-induced peritonitis, the two major doses tested (2.0 and 1.5 g/kg p.o.) were able to reduce the leukocyte migration in a dose-dependent manner. The Central Nervous System tests showed that the extract does not elicit uncoordinated motricity, hypnosis or sedating effects. The results showed that EEPL maintains the analgesic and anti-inflammatory effects of the stem bark of pacari, being the collect of leaves more favorable to the preservation of this Cerrado's native specimen.

【 授权许可】

Unknown