Antinociceptive effects of Abarema cochliacarpos (B.A. Gomes) Barneby & J.W.Grimes (Mimosaceae)

Revista Brasileira de Farmacognosia

Esquibel, Maria A.¹  Alves, Iura M.¹  Silva, Nina C. B.¹  Santos, Jaci E. S.¹  Universidade do Vale do Itajaí, Itajaí, Brazil¹  Meira, Aleandra V.¹  Cechinel-Filho, Valdir¹  Velozo, Eudes S.¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil¹  Universidade Federal do Espírito Santo, Alegre, Brazil¹  Almeida, Mara Z.¹  Associação Comunitária da Barra II, Morro do Chapéu, Brazil¹  Universidade Federal da Bahia, Salvador, Brazil¹  Campos-Buzzi, Fátima de¹ 

关键词: Abarema cochliacarpos;    analgesic effects;    medicinal plant;    phytochemical profile.;   

DOI  :  10.1590/S0102-695X2009000100011

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

In this study, we investigated the analgesic activity of crude aqueous and methanol extracts obtained from Abarema cochliacarpos bark in mice, and analyzed its phytochemical profile. All the extracts exhibited analgesic properties against the writhing test in mice, but the aqueous and methanol extracts were more active, and more potent than two known analgesic and anti-inflammatory drugs used as reference. They were also active against the capsaicin-model, but inactive when evaluated in the hot-plate test. Phytochemical studies revealed the presence of saponins, catechins, tannins, phenols and anthraquinones.

【 授权许可】

Unknown