In vitro screening of antibacterial activity of the latex and extracts from Croton urucurana Baillon

Revista Brasileira de Farmacognosia

Silva, Regilane M.¹  Lima, Joaquim C. S.¹  Oliveira, Iris S.¹  Martins, Domingos T. O.¹  Universidade Federal de Mato Grosso, Cuiabá, Brasil¹ 

关键词: Croton urucurana;    Euphorbiaceae;    Antibacterial activity.;   

DOI  :  10.1590/S0102-695X2008000400016

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

We evaluated the antibacterial activity of the latex and extracts from different polarities and pharmacogens of Croton urucurana using antimicrobial assays. The pharmacogens were collected in Barão de Melgaço-MT. The extracts were obtained by cold maceration in hexane, dichloromethane, ethyl acetate, ethanol and chloroform. They were concentrated in rotatory evaporator and dried in stove. In the disk diffusion assay, the latex showed a potent action against all bacterial strains, excepting E. coli, not differing in the potency and antibacterial spectrum. The hexane, dichloromethane and ethanol extracts of leaves showed activity against S. pyogenes, K. pneumoniae, P. aeruginosa, S. typhimurium, S. aureus and S. epidermidis in the major doses. Extracts obtained of stem bark were actives against S. aureus, S. epidermidis, P. aeruginosa, E. faecalis, S. pyogenes, E. coli, K. pneumoniae and S. typhimurium. The latex showed higher potency and broad-spectrum of action than extracts from stem bark and leaves. Among the stem bark extracts, the chloroform was the most potent one, followed by the ethanol extract. This result suggests the presence of different active principles. In the broth-microdilution, the latex and all extracts showed activity, even though, the latex presented more potency. Our results indicate that C. urucurana presents antibacterial activity, in different parts of the plant and by different secondary metabolites.

【 授权许可】

Unknown