Anti-inflammatory activity of the ethanol extract of Conocliniopsis prasiifolia R.M. King & H. Robinson in the neutrophils cellular response

Revista Brasileira de Farmacognosia

Diniz, Margareth de Fátima Formiga Melo¹  Universidade Federal da Paraíba, João Pessoa, Brasil¹  Silva, Maria das Graças da¹  Takemura, Orlando Seiko¹  Oliveira, Fernando de Sousa¹ 

关键词: Conocliniopsis prasiifolia;    Asteraceae;    Anti-inflammatory activity;    Neutrophils degranulation;    Flavonoid.;   

DOI  :  10.1590/S0102-695X2008000400012

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Conocliniopsis prasiifolia (DC) R.M. King & H. Robinson is a species used in popular medicine with anti-inflammatory and analgesic activities, it belongs to the Asteraceae family and is known as "mentrasto-roxo". Studies of the ethanol extract from its leaves (EECp) showed a low toxicity throughout oral and intraperitoneal routes, and anti-inflammatory and analgesic effects in animal models. The aim of this study was to evaluate the effect of EECp in the neutrophils degranulation for better characterization of its anti-inflammatory effect. Peritoneal neutrophils from rats and spectrophotometric techniques were used. The results showed that the EECp (25 and 50 µg/mL) was able to inhibit significantly (p<0.05) the neutrophils degranulation induced from fMLP. We can conclude that the EECp prevents the release of granules of the neutrophils that contains degrading enzymes, demonstrating anti-inflammatory activity.

【 授权许可】

Unknown