Toxicological evaluation of the essential oil of Piper aduncum L.

Revista Brasileira de Farmacognosia

Universidade Federal do Pará, Belém, Brasil¹  Maia, José Guilherme S.¹  Rocha, José Carlos S.¹  Barros, Carlos A. L.¹  Sousa, Pergentino J. C.¹  Lira, Denisléia S.¹  Monteiro, Gisele M.¹ 

关键词: Piper aduncum;    Piperaceae;    essential oil;    acute toxicity;    subacute toxicity.;   

DOI  :  10.1590/S0102-695X2008000200013

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The aim of this work was the acute and subacute toxicological evaluation of the essential oil of Piper aduncum with the determination of the LD50 in mice and the analysis of their hematological and biochemical parameters in rats. The plant is used in the Amazon folk medicine for several diseases and the phenylpropanoid dilapiolle is the main constituent of its essential oil, possessing insecticidal, fungicidal, bactericidal, larvicidal and molluscicidal properties. The LD50 was 2.400 ± 191.7 mg/kg. The essential oil did not change the hematological and biochemical parameters in a significant manner when compared with the control in the subacute treatment, excepting the reduction of creatinine. The LD50 and the hematological and biochemical results have suggested that the essential oil presents low toxicity.

【 授权许可】

Unknown