Anais da Academia Brasileira de Ciências | |
Effect of leaf essential oil from Piper solmsianum C.DC. in mice behaviour | |
Davyson L. Moreira2  PatrÍcia O. Souza2  Maria Auxiliadora C. Kaplan2  Nuno A. Pereira1  Geraldo L. Cardoso1  Elsie F. GuimarÃes1  | |
[1] ,Universidade Federal do Rio de Janeiro Núcleo de Pesquisas de Produtos Naturais Rio de Janeiro RJ ,Brazil | |
关键词: Piperaceae; Piper solmsianum; essential oil; sarisan; psychopharmacologic effect; Piperaceae; Piper solmsianum; óleo essencial; sarisan; psicofarmacologia; | |
DOI : 10.1590/S0001-37652001000100004 | |
来源: SciELO | |
【 摘 要 】
The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of monoterpenes, sesquiterpenes and of arylpropanoids. The compound sarisan, a myristicin analogue, was isolated from the oil to perform the pharmacological tests. Emulsions of the oil and of sarisan (5.0 and 10.0% v/v) were used in the tests. Pentobarbital (30 mg/ kg s.c.) or diazepam (2.5 mg/ kg s.c.) were tested as standard drugs to verify depressant or anxiolytic effects, respectively. Both essential oil and sarisan showed to have exciting and depressant effects in the tested animals.
【 授权许可】
CC BY
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