Effect of leaf essential oil from Piper solmsianum C.DC. in mice behaviour

Anais da Academia Brasileira de Ciências

Davyson L. Moreira²  PatrÍcia O. Souza²  Maria Auxiliadora C. Kaplan²  Nuno A. Pereira¹  Geraldo L. Cardoso¹  Elsie F. GuimarÃes¹ 

[1] ,Universidade Federal do Rio de Janeiro Núcleo de Pesquisas de Produtos Naturais Rio de Janeiro RJ ,Brazil

关键词: Piperaceae;    Piper solmsianum;    essential oil;    sarisan;    psychopharmacologic effect;    Piperaceae;    Piper solmsianum;    óleo essencial;    sarisan;    psicofarmacologia;   

DOI  :  10.1590/S0001-37652001000100004

来源: SciELO

【 摘 要 】

The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of monoterpenes, sesquiterpenes and of arylpropanoids. The compound sarisan, a myristicin analogue, was isolated from the oil to perform the pharmacological tests. Emulsions of the oil and of sarisan (5.0 and 10.0% v/v) were used in the tests. Pentobarbital (30 mg/ kg s.c.) or diazepam (2.5 mg/ kg s.c.) were tested as standard drugs to verify depressant or anxiolytic effects, respectively. Both essential oil and sarisan showed to have exciting and depressant effects in the tested animals.

【 授权许可】

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