GC-MS analysis and cardiovascular activity of the essential oil of Ocotea duckei

Revista Brasileira de Farmacognosia

Silva, Marcelo S.¹  Barbosa-Filho, José M.¹  Universidade Federal do Ceará, Fortaleza, Brazil¹  Machado, Maria Iracema L.¹  Universidade Federal da Paraíba, Campina Grande, Brazil¹  Dias, Celidarque S.¹  Athayde-Filho, Petrônio F.¹  Cunha, Renildo M.¹  Medeiros, Isac A.¹  Craveiro, Afrânio A.¹  da-Cunha, Emídio Vasconcelos L.¹  Universidade Federal da Paraíba, João Pessoa, Brazil¹ 

关键词: Ocotea duckei;    Lauraceae;    essential oil;    GC-MS analysis;    cardiovascular activity.;   

DOI  :  10.1590/S0102-695X2008000100009

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The essential oils obtained by steam distillation from the roots, stems, leaves and fruits of Ocotea duckei had their composition analyzed by GC-MS. The pharmacological activity of these oils was also evaluated showing significant cardiovascular effects. Forty-nine substances were identified, consisting of a complex mixture of monoterpenes (45%) and sesquiterpenes (55%). The fruits yielded (1.9%) more essential oil than the stems (1.0%), roots (0.8%) and leaves (0.7%). The main component in the oil of the leaves was trans-caryophyllene (60.54%), in the stem bark b-eudesmol (27.51%) and in the fruits, dl-limonene (30.12%). The predominant essential oil component in the roots was elemol (24.31%). In non-anaesthetized normotensive rats, the essential oils from different parts of Ocotea duckei (leaves, fruits, stem and roots) induced significant (p < 0.05) hypotension followed by bradycardia.

【 授权许可】

Unknown