Chemical composition and antitumor activity of different wild varieties of Moroccan thyme

Revista Brasileira de Farmacognosia

M’barek, Lahcen Ait¹  Jaafari, Abdeslam¹  Rakib, El Mostapha¹  Mouse, Hassan Ait¹  Benbakhta, Chouaib¹  Institut National d’Hygiène¹  Abbad, Aziz¹  Faculté des Sciences et Techniques¹  Boulli, Abdelali¹  Tilaoui, Mounir¹  Zyad, Abdelmajid¹ 

关键词: Thymus;    Lamiaceae;    GC/MS;    chemical composition;    carvacrol;    thymol;    antitumor activity.;   

DOI  :  10.1590/S0102-695X2007000400002

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Many species of Thyme have been widely used in Moroccan folk medicine as anti-inflammatory, antioxidant and antinociceptive agents. This study was designed to examine the chemical composition and the in vitro antitumor activity of the essential oils and various extracts of thyme species collected in different regions of Morocco. The essential oil, obtained by hydrodistillation, and the various extracts, obtained by Soxhlet extraction, using solvents of varying polarity, were analysed by gas chromatography coupled to mass spectrometry (GC-MS). Both major and trace components were analysed. Overall, the major constituents in the chemical composition of Moroccan thyme populations were carvacrol, thymol, borneol and p-cymene. The rate of these components can hit respectively to 85%, 42%, 59%, and 23%. Furthermore, the essential oils as well as two pure products (carvacrol and thymol) were tested for their antitumoral activity against P815 mastocytoma cell line. While all these products showed a dose dependent cytotoxic effect, the carvacrol was the most cytotoxic one compared to the others. Interestingly, when these products were tested against the normal human peripheral blood mononuclear cells, they show a proliferative effect instead of a cytotoxic one.

【 授权许可】

Unknown