Analgesic and antiedematogenic activities of wild and micropropagated Polygala paniculata L (Polygalaceae)

Revista Brasileira de Farmacognosia

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil¹  Lage, C.L.S.¹  Menezes, F.S.¹  Matheus, M.E.¹  Fernandes, P.D.¹  Fernandes, S.B.O.¹  Nogueira, F.L.P.¹  Reis, G.M.¹ 

关键词: Polygala paniculata;    Polygalaceae;    micropropagation;    analgesic activity;    antiedematogenic activity.;   

DOI  :  10.1590/S0102-695X2005000400009

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The ethanolic extracts of Polygala paniculata L. (Polygalaceae), wich is a herbaceous plant widely distributed all over Brazil, were tested for their analgesic effects using hot plate, tail flick and formalin test models, and for their antiedematogenic effects using croton oil induced ear oedema. The ethanolic extracts obtained from wild and micropropagated plants produced analgesic effects against thermal and chemical induced pain. The highest results were observed at the dose of 400 mg/kg. The inhibition of ear oedema in mice was also observed after treatment with ethanolic extract of Polygala paniculata. The effects produced by micropropagated plants were lower than wild plants, whereas both had produced significant effects. These results suggest that the ethanolic extracts from wild and micropropagated Polygala paniculata possess analgesic and antiedematogenic effects.

【 授权许可】

Unknown