Effect on Physiological Variables and Urinary Metabolites following a Single Dermal Application of Sulphur Mustard in Rats

Defence Science Journal

Om Kumar¹  R. Vijayaraghavan² 

[1] Defence Research & Development Establishment, Gwalior;Defence Research & Development Establishment, Gwalior.

关键词: Sulphur mustard;    Urinary excretions;   

DOI  :  

学科分类：社会科学、人文和艺术（综合）

来源: Defence Scientific Information & Documentation Centre

【 摘 要 】

The effect of single dermal application ofdifferent doses of sulphur mustard (2,2'-dichlorodiethyl sulphide, SM),i.e.5, 10 and 20 mg/kg body weight on some physiological variables,viz., body weight, intake of food and water, and excretion of excretaand urine was studied for one week. Levels of urinary metabolites, uricacid, urea, protein, creatine and creatinine were measured at 0, 1, 2,and 7 days in albino rats of Wister strain. A progressive dose-dependentfall in body weight was observed from day onwards after SM application.Feed and water intake were reduced significantly. Excretion of urineand exdreta was also affected adversely. The level of uric acid, ametabolite of purine bases, increased 24 hr post-exposure, in a time anddose-dependent manner. Excretion of urea decreased and the level ofcreatine increased drastically on 7th day. However, urinary excretionsof protein and creatinine did not change. The study shows that singleapplication of SM in rats induces a catabolic state.

【 授权许可】

Unknown