Progenitor Cells as a Bridging Therapy for Radiation Casualties (Review Paper)

Defence Science Journal

Thomas M. Seed³  Vijay K. Singh¹  Pankaj Kumar Singh²  Darren S. Brown² 

[1] Uniformed Services University of the Health Sciences, Bethesda;Armed Forces Radiobiology Research Institute, Bethesda;Tech Micro Services, Bethesda, MD

关键词: Gamma-radiation;    granulocyte-colony stimulating factor;    hematopoietic progenitors;    mice;    myeloid progenitors;    transfusion;   

DOI  :  

学科分类：社会科学、人文和艺术（综合）

来源: Defence Scientific Information & Documentation Centre

【 摘 要 】

Hematopoiesis is the process by which daughter cells of multipotential, self-renewing stem cells progress along differentiation pathways to become progressively more committed to specific lineages while losing their self-renewal capacity. Leucopenia and thrombocytopenia after ionising radiation exposure are due largely to injury to stem cells and progenitors in the hematopoietic tissue of the bone marrow; and in mice, the spleen. Recovery depends on the ability of the remaining stem cells and progenitors to proliferate and differentiate sufficiently to reconstitute the immune system before it is challenged by potential microorganisms and lethal infections occur. This mini review discusses various approaches to the mobilisation of progenitors and their utility as a bridging therapy for radiation casualties. Defence Science Journal, 2011, 61(2), pp.118-124 , DOI:http://dx.doi.org/10.14429/dsj.61.831

【 授权许可】

Unknown