Role of some fermentation parameters on cyclosporin A production by a new isolate of Aspergillus terreus

The Journal of General and Applied Microbiology

Ibrahim S. Abdel-Salam¹  Hassaan A. El-Minofi¹  Abdel-Hamid A. Hamdy¹  Lotfy A.R. Sallam¹  Abdel-Monem H. El-Refai¹ 

[1] Microbial and Natural Products Chemistry Department, National Research Centre

关键词: Aspergillus terreus;    cyclosporin A;    fermentation conditions;   

DOI  :  10.2323/jgam.49.321

学科分类：微生物学和免疫学

来源: Applied Microbiology, Molecular and Cellulrar Biosciences Research Foundation

【 摘 要 】

A local isolate of Aspergillus terreus was selected among different microorganisms as a new cyclosporin A (Cy A) producing culture. The formation of Cy A was investigated under different fermentation conditions (including selection of the cultivation medium, fermentation time course, inoculum nature, medium volume, agitation rate, pH value). Relatively high Cy A productivities were maintained when the fermentation process was carried out using a medium composed of (g/L): glucose, 50; bactopeptone, 10; KH2PO4, 5; KCl, 2.5; pH 5.3, inoculated with 2% standard inoculum of 48h age, shaken at 200rpm for 10 days.

【 授权许可】

Unknown