Survival of Transfused CD18-Positive Granulocytes and Their Chemiluminescent Response in a Heifer with Leukocyte Adhesion Deficiency

Journal of Veterinary Medical Science

Hajime NAGAHATA³  Gary J. KOCIBA²  Kotose NIOKA¹  Susumu MATSUKI³  Takeo MIURA³  Naoto SAKURAI³ 

[1] Souya District Agricultural Mutual Aid Association;Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University;Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University

关键词: BLAD;    CD18-positive cell;    granulocyte transfusion;   

DOI  :  10.1292/jvms.60.261

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(6)Cited-By(2)Granulocyte transfusion (GT) was performed in an 8-month-old heifer with leukocyte adhesion deficiency (BLAD) to monitor the changes in transfused CD18-positive neutrophils and associated neutrophil chemiluminescent (CL) response in β2-integrin-deficient host. The CD18-positive neutrophils were detected in blood from the BLAD heifer during the first 3 hr after 2.6 × 109 cells were infused by GT, and disappeared by 5 hr after GT. The CL response of neutrophils was increased 1.7 to 2.8-fold in the BLAD heifer during the first 3 hr after GT, thereafter CL response decreased gradually from 2 to 5 hr after GT.

【 授权许可】

Unknown