Detection of a Quantitative Trait Locus for Intramuscular Fat Accumulation Using the OLETF Rat

Journal of Veterinary Medical Science

Hideki TANOMURA²  Kozo MATSUMOTO³  Takahisa YAMADA²  Yukio TANIGUCHI²  Noboru MANABE¹  Takeshi MIYAKE²  Yoshiyuki SASAKI²  Hiroyuki KOSE³ 

[1] Laboratory of Anatomy and Cell Biology, Graduate School of Agriculture, Kyoto University;Laboratory of Animal Breeding and Genetics, Graduate School of Agriculture, Kyoto University;Institute for Animal Experimentation, University of Tokushima School of Medicine

关键词: animal model;    intramuscular fat;    obesity;    OLETF rat;    QTL;   

DOI  :  10.1292/jvms.64.45

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(34)Cited-By(10)The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes. We showed that the OLETF rat exhibits higher levels of intramuscular fat content in Musculus longissimus as compared to the Fischer-344 (F344) rat. Our investigation was designed to identify quantitative trait loci (QTLs) contributing to the increased levels of intramuscular fat content by performing a whole-genome search using 108 F2 intercross obtained by mating the OLETF and the F344 rats. We identified one QTL responsible for intramuscular fat accumulation on rat chromosome 1 with a maximum lod score of 3.4, which accounts for 5% of the total variance. As expected, the OLETF allele corresponds to the increased levels of intramuscular fat content.

【 授权许可】

Unknown