A Case of Adrenal Insufficiency Due to Acquired Hypothalamic CRH Deficiency

Endocrine Journal

NAOKATA YOKOYAMA²  EIJUN NISHIHARA²  TAKESHI KIRIYAMA²  SHIGENOBU NAGATAKI²  TADAHIKO ISHIMARU²  HIRONORI KIMURA²  SHUNICHI YAMASHITA¹ 

[1] Department of Cell Physiology, Atomic Disease Institute, Nagasaki University School of Medicine;The First Department of Internal Medicine, Nagasaki University School of Medicine

关键词: Corticotropin releasing hormone (CRH);    ACTH;    Hypothalamus;    Adrenal insufficiency;    Chronic thyroiditis;   

DOI  :  10.1507/endocrj.44.121

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(12)Cited-By(5)A 40-year-old woman with adrenal insufficiency was clinically diagnosed and examined with human corticotropin releasing hormone (CRH). This patient with secondary hypo-adrenalism has shown a normal serum cortisol response to exogenous ACTH administration and has been examined with CRH, lysine-vasopressin (LVP) and insulin tolerance test (ITT), respectively. Success in secreting ACTH in response to both CRH and LVP tests, but not ITT, suggests that this disorder was possibly due to a hypothalamic CRH deficiency rather than pituitary corticotroph dysfunction. A combination of the CRH test and ITT has come to play an increasingly significant role in the diagnosis and differential diagnosis of isolated ACTH deficiency syndrome.

【 授权许可】

Unknown