Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Journal of Veterinary Medical Science

Shigeo HARA¹  Nobuyuki TOMIZAWA¹  Reeko SATO³  Masanobu GORYO⁴  Tatsuya NARITA² 

[1] Department of Veterinary Surgery, Faculty of Agriculture, Iwate University;Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University;Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University;Department of Veterinary Pathology, Faculty of Agriculture, Iwate University

关键词: adverse effect;    canine;    Ketoprofen;    long-term administration;   

DOI  :  10.1292/jvms.67.847

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(36)Cited-By(7)To investigate the adverse effects of long-term administration of ketoprofen in dogs, ketoprofen (1 mg/kg) was administered to five clinically healthy beagle dogs (ketoprofen group) and gelatin capsules (control group) were administered to four clinically healthy beagle dogs for 30 days. We monitored the dogs through periodic physical examination, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests, urinalysis, urinary enzyme indices and cuticle bleeding time analysis. The lesions in the stomach, especially in the pyloric antrum, and fecal occult blood progressively worsened in the ketoprofen group. However, the differences between the ketoprofen group and the control group were not statistically significant. One dog in the ketoprofen group temporarily exhibited a decrease in renal plasma flow and two dogs exhibited enzymuria. However, these changes did not persist and the other examinations showed no significant difference between premedication and postmedication in the ketoprofen group. Therefore, the adverse effects of long-term administration of ketoprofen observed in this study were not clinically important in healthy dogs. Nevertheless, further investigation of adverse renal effects from long-term administration of ketoprofen is necessary in the dogs with subclinical renal disease.

【 授权许可】

Unknown