Antimicrobial Resistance in Salmonella Strains Clinically Isolated in Hyogo, Japan (2009–2012)

Japanese Journal of Infectious Diseases

Yuma Okuya¹  Ayaka Kato¹  Akiko Nishimoto¹  Rika Shimizu¹  Hiroyuki Yoshida⁵  Masato Fujisawa⁴  Kayo Osawa¹  Yoshio Iijima²  Katsumi Shigemura⁴  Akane Kishi¹  Mayuha Kimura¹  Shunichiro Yutaka¹  Yuki Katayama¹  Toshiro Shirakawa¹  Miki Fujiwara³ 

[1] Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science;Department of Microbiology, Kobe Institute of Health;Hyogo Clinical Laboratory Corporation;Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine;Division of Infectious Diseases, Kobe University Hospital

关键词: Salmonella;    ESBL;    quinolone resistance;   

DOI  :  10.7883/yoken.67.54

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(10)Cited-By(1)The purpose of this study was to examine the in vitro susceptibilities to antimicrobial agents and genetic diversity of 195 clinical strains of Salmonella spp., which were isolated and examined for the extended-spectrum β-lactamase (ESBL) blaCTX-M gene and the presence of gyrA, gyrB, parC, and parE genes mutations in Hyogo, Japan, from 2009 to 2012. Forty-three of the 195 strains were antimicrobial resistant. Two Salmonella enterica subsp. enterica strains, 1 serovar Schwarzengrund, and 1 serovar Enteritidis were identified as ESBL-producing strains possessing blaCTX-M-15 and blaCTX-M-2, respectively. Among 8 nalidixic acid-resistant strains, 7 had mutations in gyrA alone or in gyrA and parC. In conclusion, we identified CTX-M ESBL-producing Salmonella clinical strains with multidrug resistance. Further studies are needed to monitor these serious drug-resistant Salmonella strains in Japan.

【 授权许可】

Unknown