Delayed Type Hypersensitivity Responses in Mice Transplanted with Rat Hepatocytes

Journal of Veterinary Medical Science

Michinori TANAKA¹  Shuichi FURUSAWA¹  Sanenori NAKAMA¹  Shigeyuki TANABE¹  Yasuho TAURA¹  Yoshikazu HIROTA¹  Munekazu NAKAICHI¹ 

关键词: delayed type hypersensitivity;    immunosuppression;    intrasplenic transplantation;    xenogeneic hepatocytes;   

DOI  :  10.1292/jvms.56.1143

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(34)Cited-By(1)The delayed type hypersensitivity (DTH) response to xenogeneic hepatocytes (HCs) was investigated in mice received subcutaneous (s.c.), intrasplenic (i.s.), or intravenous (i.v.) transplantation of rat HCs. The DTH response in mice preimmunized i.s. or i.v. with rat HCs (1x106 cells) was significantly lower than that in mice preimmunized s.c. with the same doses of rat HCs. Co-transfer of spleen cells from i.s. immunized mice with spleen cells from s.c. immunized mice to naive recipient mice did not suppress the DTH response induced by transfer of spleen cells from s.c. immunized mice. On the other hand, co-transfer of spleen cells from i.v. immunized mice with spleen cells from s.c. immunized mice suppressed the DTH response to rat HCs in recipients. Furthermore, the levels of DTH responses in recipients transferred with spleen cells from mice sensitized i.s. or i.v. with rat HCs, immunized s.c. with rat HCs 6 hr after transfer, and challenged with rat HCs 7 days later was almost similar to those in recipients transferred with spleen cells from s.c. immunized mice. These results suggest that antigen-specific suppression of DTH responses to rat HCs in mice is associated with the presence of suppressive spleen cells induced by i.s. or i.v. immunization with rat HCs.

【 授权许可】

Unknown