Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart

Memórias do Instituto Oswaldo Cruz

Moacir Paranhos-silva²  Lain C Pontes-de-carvalho²  Geraldo G De Sá Oliveira²  Eliane Góes Nascimento¹  Washington Lc Dos-santos² 

[1] ,Fundação do Instituto Oswaldo Cruz Centro de Pesquisas Gonçalo Moniz Salvador BA ,Brasil

关键词: Montenegro's skin test;    Leishmania;    delayed type hypersensitivity;    thimerosal;    canine visceral leishmaniasis;   

DOI  :  10.1590/S0074-02762001000500017

来源: SciELO

【 摘 要 】

Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a large proportion of dogs (11 out of 56) examined in an endemic area of leishmaniasis presented induration at the site of injection of a diluent containing thimerosal alone. This clearly demonstrates that thimerosal leads to a high number of false positive skin reactions in dogs and that its use in Montenegro's skin test antigenic preparations should be avoided.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License