Pathological Characterization of Collagenofibrotic Glomerulonephropathy in a Young Dog

Journal of Veterinary Medical Science

Ryosuke KOBAYASHI²  Kyohei YASUNO²  Munetaka YAMAKI¹  Kikumi OGIHARA⁵  Junichi KAMIIE³  Kinji SHIROTA²  Yumiko KAGAWA⁴ 

[1] Yamaki Animal Clinic;Research Institute of Biosciences, Azabu University;Laboratory of Veterinary Pathology, Azabu University;North Lab;Laboratory of Environmental Pathology, Azabu University

关键词: canine;    collagen;    glomerulonephropathy;   

DOI  :  10.1292/jvms.71.1137

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(3)This report describes the morphological and immunohistochemical findings of a case of apparent collagenofibrotic glomerulonephropathy in a 7-month-old dog. Clinical examination showed moderate protenuria with elevated blood urea nitrogen and creatinine. Histopathological examination of the glomerular capillary walls and mesangial areas revealed diffuse and global accumulation of eosinophilic homogeneous or fine fibrous materials, which were immunohistochemically positive for type III collagen. On electron microscopy, the randomly crossed fibrils had transverse bands with a periodicity of approximately 60 nm. The clinical, histopathological, immunohistochemical and electron microscopic findings of the present dog were consistent with those of the human, childhood form of collagenofibrotic glomerulonephropathy.

【 授权许可】

Unknown