Pyrrolysyl-tRNA Synthetase, an Aminoacyl-tRNA Synthetase for Genetic Code Expansion

Croatica Chemica Acta

Crnković, Ana¹  Suzuki, Tateki¹  Söll, Dieter¹  Reynolds, Noah M.¹ 

[1] Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520-8114, USA

关键词: genetic code expansion;    stop codon suppression;    pyrrolysyl-tRNA synthetase;    tRNAPyl;    synthetic biology;    non-canonical amino acid;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

Genetic code expansion (GCE) has become a central topic of synthetic biology. GCE relies on engineered aminoacyl‐tRNA synthetases (aaRSs) and a cognate tRNA species to allow codon reassignment by co-translational insertion of...

【 授权许可】

Unknown