Effect of Octreotide Acetate on the Plasma Concentration and Urinary Excretion of Uridine and Purine Bases

Endocrine Journal

TETSUYA YAMAMOTO¹  TSUNEYOSHI KA¹  YUJI MORIWAKI¹  SUMIO TAKAHASHI¹  TOSHIKAZU HADA¹  ZENTA TSUTSUMI¹ 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine

关键词: Octreotide acetate;    Uric acid;    Uridine;    Glucagon;    Insulin;   

DOI  :  10.1507/endocrj.49.139

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(22)Cited-By(1)To determine the effect of octreotide acetate on urinary excretion of uric acid and plasma concentration of uridine, we subcutaneously administered octreotide acetate (1 μg/kg of body weight) to 5 healthy subjects. Ninety minutes after administration, octreotide acetate increased the plasma concentration of uridine by 15% and decreased the plasma concentration of glucagon by 24% and that of insulin to below the detection limits. In addition, octreotide acetate decreased the urinary excretion of uric acid, sodium, and chloride by 60%, 40%, and 38%, respectively, at 1 hour after administration. However, octreotide acetate did not affect the concentrations of hypoxanthine, xanthine, uric acid, cyclic AMP in plasma, lactic acid and pyruvic acid in blood, urinary excretion of hypoxanthine and xanthine, or creatinine clearance. From these results, we speculated that octreotide acetate decreases the urinary excretion of uric acid by decreasing the concentration of glucagon and/or urinary excretion of sodium, and increases the plasma concentration of uridine via decreased concentrations of glucagon and insulin.

【 授权许可】

Unknown