Crucial Role of Insulin in Leptin Maintenance

Endocrine Journal

TAKAKO SAITO¹  TOSHIKAZU SAITO¹  TOMOATSU NAKAMURA¹  MINORI HIGASHIYAMA¹  MUTSUKO NONAKA¹  SAN-E ISHIKAWA¹  IKUYO KUSAKA¹  SHOICHIRO NAGASAKA¹  KAZUTOSHI FUJIBAYASHI¹ 

[1] Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School

关键词: Leptin;    Insulin;    GH;    Octreotide acetate;    Insulinoma;   

DOI  :  10.1507/endocrj.47.359

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(18)Cited-By(7)To further clarify the relationship between insulin and leptin, time course changes in plasma glucose, serum insulin and leptin levels were analyzed after subcutaneous administration of 100μg octreotide acetate in two insulinoma subjects. Octreotide acetate induced a prompt decrease in serum insulin level, accompanied with an increase in plasma glucose in both patients. Following the decrease in serum insulin level, serum leptin concentrations were profoundly decreased by 66% and 44%, 8-12 hrs after octreotide injection; that is, the concentrations decreased from 41.1 to 13.8ng/ml in patient 1, and from 17.5 to 9.8ng/ml in patient 2. Daily profiles of plasma glucose, serum insulin and leptin without octreotide administration did not show such alterations in these indexes in patient 1. These data show that circulating leptin may be susceptible to decline dependent on the decrease in serum insulin, suggesting that insulin plays a crucial role in the maintenance of leptin secretion in humans.

【 授权许可】

Unknown