Molecular Characterization of Interleukin-1Beta in the Tammar Wallaby (Macropus eugenii)

Journal of Veterinary Medical Science

Gavan A. HARRISON²  Lauren J. YOUNG¹ 

[1] Marsupial Immunology Research Laboratory, Centre for Environmental Management CQUniversity Australia;School of Science, Food and Horticulture, University of Western Sydney

关键词: cytokine;    IL-1β;    nterleukin-1;    Macropus eugenii;    marsupial;   

DOI  :  10.1292/jvms.10-0100

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(6)Interleukin-1beta (IL-1β) plays a significant role in the onset and pathogenesis of inflammation in mammalian hosts. Although well characterized in a range of vertebrate species, little is known about this important cytokine in marsupial mammals. We report here the molecular cloning and characterization of IL-1β in the tammar wallaby (Macropus eugenii). M. eugenii IL-1β has an open-reading frame of 813 nucleotides, coding for a putative protein of 270 amino acids to the termination codon. The IL-1 family motif and potential caspase cleavage site (necessary for production of the mature protein) is also present in the sequence. Molecular characterization of tammar wallaby IL-1β provides fundamental information necessary to progress the study of functional immune responses in this unique group of mammals.

【 授权许可】

Unknown