Journal of Veterinary Medical Science | |
Molecular Characterization of Interleukin-1Beta in the Tammar Wallaby (Macropus eugenii) | |
Gavan A. HARRISON2  Lauren J. YOUNG1  | |
[1] Marsupial Immunology Research Laboratory, Centre for Environmental Management CQUniversity Australia;School of Science, Food and Horticulture, University of Western Sydney | |
关键词: cytokine; IL-1β; nterleukin-1; Macropus eugenii; marsupial; | |
DOI : 10.1292/jvms.10-0100 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(30)Cited-By(6)Interleukin-1beta (IL-1β) plays a significant role in the onset and pathogenesis of inflammation in mammalian hosts. Although well characterized in a range of vertebrate species, little is known about this important cytokine in marsupial mammals. We report here the molecular cloning and characterization of IL-1β in the tammar wallaby (Macropus eugenii). M. eugenii IL-1β has an open-reading frame of 813 nucleotides, coding for a putative protein of 270 amino acids to the termination codon. The IL-1 family motif and potential caspase cleavage site (necessary for production of the mature protein) is also present in the sequence. Molecular characterization of tammar wallaby IL-1β provides fundamental information necessary to progress the study of functional immune responses in this unique group of mammals.
【 授权许可】
Unknown
【 预 览 】
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