Canine Bone Marrow Stromal Cells Promote Functional Recovery in Mice with Spinal Cord Injury

Journal of Veterinary Medical Science

Hiroshi NAKAZAWA⁴  Tomoya HARAGUCHI³  Kenji TANI⁴  Yasutaka ODA⁵  Kazuhito ITAMOTO³  Yusuke ASARI⁴  Yutaka MOMOTA⁶  Masaaki KATAYAMA¹  Yasuho TAURA⁴  Luiz Fernando QUINTANILHA² 

[1] Division of Small Animal Surgery, Department of Veterinary Science, Faculty of Agriculture, Iwate University, 3�?18�?8 Ueda, Morioka, Iwate 020�?8550, Japan;Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami-Kogushi 1�?1�?1 Ube, Yamaguchi 755�?8505, Japan;Animal Medical Center, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677�?1 Yoshida, Yamaguchi 753�?8515, Japan;Department of Veterinary Surgery, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677�?1 Yoshida, Yamaguchi 753�?8515, Japan;The United Graduate School of Veterinary Science, Yamaguchi University, 1677�?1 Yoshida, Yamaguchi 753�?8515, Japan;Department of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, 1�?7�?1 Kyonan-cho, Musashino, Tokyo 180�?8602, Japan

关键词: bone marrow stromal cell (BMSCs);    canine;    mouse;    spinal cord injury;    transplantation;   

DOI  :  10.1292/jvms.13-0587

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantation therapy was performed, immediately after the spinal cord was injured. Canine BMSC therapy enhanced functional recovery of the hind limbs in mice with SCI. Nestin-positive cells were observed only in the lesion of mice with SCI that received BMSCs. These results suggest that canine BMSCs promote functional recovery in mice with SCI and that migration of nestin-positive cells may contribute to the efficacy of the BMSC treatment.

【 授权许可】

Unknown