Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin–Bound Paclitaxel in Rats

Journal of Pharmacological Sciences

Soichiro Ushio¹  Nobuaki Egashira¹  Yuji Yamashita¹  Ryozo Oishi¹  Ken Masuguchi¹  Takehiro Kawashiri¹ 

[1] Department of Pharmacy, Kyushu University Hospital, Japan

关键词: nanoparticle albumin–bound paclitaxel;    paclitaxel;    peripheral neuropathy;   

DOI  :  10.1254/jphs.11062SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(11)Cited-By(2)Nanoparticle albumin–bound paclitaxel (nab-paclitaxel) is delivered to tumors and increases antitumor activity compared with solvent-based paclitaxel. However, in a clinical trial, higher and lower rates of peripheral neuropathy and neutropenia were observed. In this study, we compared the effects of nab-paclitaxel and standard paclitaxel on pain behaviors in rats. Repeated administration of nab-paclitaxel dose-dependently induced both mechanical and cold allodynia, and the effects of nab-paclitaxel on pain behaviors tended to be stronger than that of standard paclitaxel at the doses used clinically. These results suggest that closer attention must be paid to the neuropathy when administering nab-paclitaxel in clinical settings.

【 授权许可】

Unknown