Morphological Analysis of Corneal Opacity in Shiba Dog with GM1 Gangliosidosis

Journal of Veterinary Medical Science

Prasarn TANGKAWATTANA³  Keiko TSUZUKI²  Aya NAGAYASU¹  Yoshinao HOSAKA¹  Kazushige TAKEHANA¹  Taito NAKAMURA¹  Hiromi UEDA¹  Osamu YAMATO⁴ 

[1] Department of Veterinary Anatomy, Rakuno Gakuen University;Veterinary Teaching Hospital, Rakuno Gakuen University;Department of Veterinary Anatomy, Faculty of Veterinary Medicine Khon Kean University;Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University

关键词: corneal opacity;    GM1 gangliosidosis;    keratocyte;    Shiba dog;   

DOI  :  10.1292/jvms.70.881

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(3)GM1 gangliosidosis is one of the inherited metabolic lysosomal storage disorders characterized by neurological symptoms caused by β-galactosidase deficiency and consequent accumulation of GM1 ganglioside in neuronal cells. Shiba dogs affected with GM1 gangliosidosis have been found to suffer from corneal opacity. In our morphological analysis, keratocyte enlargement was induced by abnormal intracellular accumulation of neutral carbohydrates, resulting in the loss of normal arrangement of collagen fibrils in the opaque cornea was found to be associated with the disorder. We therefore conclude that corneal opacity in this Shiba dog with GM1 gangliosidosis may be caused by neutral carbohydrate accumulation in lysosomes, swelling and dysfunction of keratocytes, and subsequent irregular arrangement of collagen fibrils in the corneal proper substance.

【 授权许可】

Unknown